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KMID : 0388220090160010054
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Journal of the Korean Rheumatism Association
2009 Volume.16 No. 1 p.54 ~ p.58
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A Case of IgA Nephropathy Associated with Systemic Lupus Erythematosus
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Bane So-Young
Kim Gheun-Ho
Shin Dong-Ho
Park Moon-Hyang
Jun Hey-Jung
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Abstract
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Renal involvement is frequently seen in patients with systemic lupus erythematosus (SLE). The occurrence of non-lupus nephritis, and especially IgA nephropathy, in SLE patients has rarely been reported. We describe here the case of a 30-year-old woman who had systemic lupus erythematosus and nontuberculous mycobacterial lung disease, and her biopsy of a renal lesion was unexpectedly diagnostic of IgA nephropathy. Although both IgA nephropathy and lupus nephritis are immune complex mediated diseases, their laboratory and histopathologic findings and the extra-renal clinical manifestations are different and these all support a different pathogenesis for the 2 diseases. Renal biopsy plays a crucial role in identifying and diagnosing renal lesions, which may have prognostic and therapeutic implications that are distinct from those of lupus nephritis. In conclusion, performing a renal biopsy in SLE patients who have urinary abnormalities is important since a correct diagnosis would permit the most appropriate treatment to be started and so avoid unnecessary immunosuppressive treatments.
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KEYWORD
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IgA nephropathy, Systemic lupus erythematosus, Non-tuberculous mycobacterium
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